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What's the difference in topically and sublingually applying cannabinoids to skin?

May 4

What's the difference in topically and sublingually applying cannabinoids to skin? 


The new CBD lotion Extra-strength formula has 2000mg CBD/CBD 1 to5 ratio. This includes 15% arnica oil, plus the additional benefits from shea butter and other essential oils. What's the difference in topically and sublingually applying cannabinoids to skin? Let's see...

Cannabinoids may be inhaled by vape rigs, sublingually, or orally. CBD can be found in many cosmetic products including creams and lotions. How does cannabinoids affect skin? Is it possible for them to penetrate the protective barrier, or does their effect reach deeper beneath the skin?

Can cannabinoids still be absorbed through the skin?

A lot of people believe that the cannabinoid enters the body when they apply cannabinoid creams to their skin. This is an assumption that can be challenged. It depends. You can apply CBD to your skin in two ways: transdermal or topical.

Topical applications refers to creams, ointments and lotions that can be applied to the skin's topmost layer. These products are targeted at skin and do NOT transport cannabinoids to blood vessels below.

Transdermal CBD products, however, penetrate the skin's outer layers and reach into the bloodstream. Transdermal CBD Gels have been shown in studies to increase plasma levels and make CBD more readily available.

Transdermal CBD doesn’t necessarily mean that you need to apply the cannabinoid directly to your skin. You need several adjuvants in order to create a hydroalcoholic jelly that penetrates your epidermis.

Transdermal cannabinoids were not extensively studied but it is possible to bypass the digestive process and deliver cannabinoids directly through the skin. This administration method works in the same way as sublingual ingestion. Transdermal cannabinoids are covered by multiple patents.

What does cannabinoids have to do with the skin?

Transdermal delivery allows cannabinoids to be delivered directly into the bloodstream via transdermal delivery. The advantage of topical products is however distinct. Skin has cannabinoid receptors, just like other parts. The body's regulatory system the endocannabinoid, (ECS), plays a vital role in many biological systems maintaining homeostasis. The skin is not the only exception.

Trends In Pharmacological Sciences has published a review that stated that the skin’s endocannabinoid and other systems play a vital role in many crucial processes. External cannabinoids are similar in structure to the ones found in the body and target identical receptors.

Cannabinoids for dermatological problems

Numerous studies have looked at the effects cannabinoids have on dermatological problems. The study on cannabinoids and keratinocyte growth was published in Journal of Dermatological ScienceThis condition is frequently associated with flaky or red skin.

These uncomfortable symptoms can be explained by the immune system attacking healthy cells of the skin, which is a problem in homeostatic regulation. This leads to a rapid accumulation and destruction of skin cells. CBD, CBN, THC and CBD were found not to affect keratinocyte growth and restored skin balance. Further research continues to confirm these findings.

Researchers also studied how cannabinoids influence sebum production. This oily substance may build up in the pores and lead to bacteria. Research published Journal of Clinical InvestigationThe study looked at the effects of CBD oil upon human sebocytes, cells that produce high levels of sebum. The CBD may be able help these cells function normally, acting on A2A receptors and TRPV4 receivers, researchers found.

Conclusion: Cannabinoids for skin

Even though research is still very early, it's evident that cannabinoids are having interesting effects on skin. There have been many questions about the role of cannabinoids in dermatology and the impact of dermatology research on the skin since the discovery of ECS in the largest organ of our bodies.