Home News CBD and Epilepsy: The Charlotte Figi Story

CBD and Epilepsy: The Charlotte Figi Story

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They purchased all of it and had a pal extract the oil. 

After they administered the extracted CBD oil, their daughter noticed a outstanding discount in seizures.

In reality, she didn’t have one other seizure for 7 days. 

Her father, Matt, described to CNN following her continued remedy that, “I actually see Charlotte’s mind making connections that have not been made in years.” 

As compared, there have been factors the place Charlotte couldn’t stroll earlier than she started CBD remedy.

Immediately, the authorized boundaries surrounding CBD’s potential as an anti-seizure drug have been all however pulled down. 

33 states offer medical marijuana and 10 extra supply hashish for all adults.

As hashish’ acceptance has grown over the previous decade, CBD has been adopted within the mainstream.

Late final June, the FDA authorised Epidiolex, making it the primary government-sanctioned cannabis-derived substance for these with extreme types of epilepsy.

Now, like Charlotte, these 2 years of age and older with Dravet syndrome and Lennox-Gastaut syndrome (LGS) who don’t reply to present drugs could use epidiolex.

As hashish acceptance grows nationwide, demand for chemical compounds derived from the plant, together with CBD, has elevated.

However why does CBD assist these with extreme seizure problems?

To reply this query, we should go contained in the physique’s endocannabinoid system or ECS. 

We additionally will study how nervousness, a typical co-occurring dysfunction, could coloration CBD’s results.

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The ECS exists all through the human physique as a system of receptors and chemical compounds. 

Endocannabinoid programs will be present in animals in addition to people, and so they present useful models for investigators to additional perceive the human ECS and the way hashish chemical compounds like CBD act upon it.

Two forms of receptors, CB1 and CB2, populate the ECS. These receptors work along with ECS chemical compounds to regulate many important physiological processes

These embrace however are usually not restricted to starvation, ache sensation, reminiscence, wakefulness, and, necessary for our functions, processes particular to seizure discount.

Inside your endocannabinoid system, your physique produces chemical compounds often called endocannabinoids. 

These endocannabinoids, like anandamide or 2-AG, bind to and block the CB1 and CB2 receptors that make up the ECS, working in a sequence as regulators for bodily processes.

For instance, when the ECS releases anandamide, it produces feel-good results just like that of an endorphin. 

After a sure period of time, fatty acid amide hydrolase, or FAAH, is launched, which metabolizes anandamide. 

FAAH acts like an anandamide break, switching on and off to control issues like sleep, appetite, and digestion.

Studies show that cannabis-related chemical compounds like CBD and THC will bind to your CB1 receptors, blocking FAAH, and subsequently extending its feel-good results. 

Particularly, FAAH’s motion could assist explain CBD’s vast anecdotal evidence as a seizure support.